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DNA damage-triggered generation of SSADs was found to be crucial for the specific binding and the subsequent formation of short DNA-RNA duplexes that was the initial step for the formation of large hairpin-loops and its retro-translocation. Subsequently, the formation of δ-core DNA dodecamers was facilitated through hybridization of the SSAD-dsDNA with the δ-core duplex, which is composed of two looped duplexes formed by base pairing of the three single-stranded regions of the δ-core structure. Upon the formation of the δ-core DNA dodecamers, the formation of the large hairpin-loop and its retro-translocation was enhanced. As a result, the formation of the δ-core DNA dodecamers triggered the effective and specific binding of RNase H1 to the target mRNA for the mRNA knock-down activity. Collectively, these results suggest that the small-DNA-triggered gene expression regulation is presumably initiated by the formation of the δ-core DNA dodecamer that can trigger the specific binding of the RNase H1 for the down-regulation of the target mRNA.Scientists from the U.S., England and Switzerland have created a way to "digest" air molecules using diamond nanoparticles. Called chemical vapor sensing, it can detect airborne toxic and hazardous materials more quickly and accurately than current techniques and promises to cut unnecessary, costly air quality tests at airport security checkpoints. Diamantene, the manufacturer of the new sensor, chose the information-packed title "Piecing Together the Environment" for this groundbreaking technology. At heart, the new sensor is essentially a diamond nanoparticle " What's New in the? Mycobacterium tuberculosis sonicate-induced apoptosis of monocytes: involvement of tumor necrosis factor-alpha. 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M. tuberculosis-induced apoptosis of monocytes was observed in patients with ATB (from 90% to 50%, p = 0.04), but not in those with LTB. M. tuberculosis sonicate induces apoptosis of monocytes through the release of TNF-alpha.UPDATES with video at 11pm -- Councilmember and mayoral candidate Johnna Grimm called for the arrest of a man who harassed her with threats for nearly two years as a ticket inspector at a New Orleans Holiday in Lights Festival event. While Grimm was disputing traffic tickets on New Year's Day 2004, Robert Deruyf, a 58-year-old New Orleans resident, was arrested for making threats against her and for criminal trespassing. Grimm spoke for the first time about the incident on National Public Radio's Fresh Air. When Deruyf was arrested, Grimm spoke of the incident with a crowd of people who were supportive. "He said, 'I'm going to run into the crowd and kick your a*s out.' 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